Prevalence and risk factors of neurodevelopmental disorders among patients with inborn errors of immunity
Dr. Vivian Chen, PGY2
Supervisor: Dr. Rae Brager, Associate Professor, Pediatrics, McMaster University
Inborn errors of immunity (IEI) encompass a diverse group of rare genetic disorders that impair immune system development and function. Advances in screening and treatment regimens have led to improved survival rates for children with IEI, making long-term outcomes, particularly neurodevelopment, an increasingly important area of concern. This systematic review aims to examine and synthesize the available evidence on neurodevelopmental disorders in patients diagnosed with inborn errors of immunity (IEI), focusing on the following: 1) Assessing the prevalence of neurodevelopmental disorders in patients with IEI, 2) Identify the potential role of factors such as type of IEI, infections, hospitalizations, and treatments in influencing neurodevelopmental outcomes in these patients.
macpedsrrt.ca 